Custom Essays, Research Papers & Assignment Help Services

Fill the order form details - writing instructions guides, and get your paper done.

Posted: October 5th, 2023

Pathophysiology of Cardiac Remodeling in Heart Failure:

Pathophysiology of Cardiac Remodeling in Heart Failure: Mechanisms and Therapeutic Targets

Pathophysiology of Cardiac Remodeling in Heart Failure: Mechanisms and Therapeutic Targets.
Cardiac remodeling is a term that refers to the structural and functional changes that occur in the heart as a result of various stimuli, such as myocardial infarction, hypertension, or valvular disease. Cardiac remodeling can be adaptive or maladaptive, depending on the type, duration, and intensity of the stimulus, as well as the genetic and environmental factors that influence the response of the myocardium. Adaptive remodeling aims to preserve or improve cardiac function and maintain hemodynamic stability, while maladaptive remodeling leads to progressive deterioration of cardiac function and increased risk of heart failure (HF) and death.

The pathophysiology of cardiac remodeling involves complex interactions among mechanical stress, neurohumoral activation, inflammation, oxidative stress, apoptosis, autophagy, fibrosis, hypertrophy, and angiogenesis. These processes affect the cardiomyocytes, the extracellular matrix (ECM), and the coronary vasculature, resulting in changes in the size, shape, mass, and composition of the cardiac chambers. The most common type of cardiac remodeling is left ventricular (LV) remodeling, which is characterized by LV dilation, spherical deformation, wall thinning, increased LV mass, and reduced LV ejection fraction (LVEF). LV remodeling is associated with increased LV wall stress, impaired diastolic and systolic function, arrhythmias, and adverse clinical outcomes.

Several therapeutic strategies have been developed to prevent or reverse cardiac remodeling and improve the prognosis of patients with HF. These include pharmacological interventions, such as angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), beta-blockers, mineralocorticoid receptor antagonists (MRAs), neprilysin inhibitors, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and anti-inflammatory agents; device-based therapies, such as cardiac resynchronization therapy (CRT), implantable cardioverter-defibrillators (ICDs), left ventricular assist devices (LVADs), and transcatheter aortic valve replacement (TAVR); and surgical procedures, such as coronary artery bypass grafting (CABG), mitral valve repair or replacement, and ventricular reconstruction. These therapies target different aspects of the pathophysiological mechanisms of cardiac remodeling and aim to restore or improve cardiac structure and function.

In this paper, we will review the current knowledge on the pathophysiology of cardiac remodeling in HF, focusing on the molecular and cellular mechanisms involved in the process. We will also discuss the therapeutic targets and interventions that have been shown to modulate cardiac remodeling and their clinical implications.

References:

– Colucci WS. Pathophysiology of heart failure with reduced ejection fraction: Hemodynamic alterations and remodeling. UpToDate. 2022. Available from: https://www.uptodate.com/contents/pathophysiology-of-heart-failure-with-reduced-ejection-fraction-hemodynamic-alterations-and-remodeling
– Chai R., Xue W., Shi S., et al. Cardiac Remodeling in Heart Failure: Role of Pyroptosis and Its Therapeutic Implications. Front Cardiovasc Med. 2022;9:870924. doi: 10.3389/fcvm.2022.870924
– Fuster V., Kelly B.B., Vedanthan R., eds. Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health. Washington (DC): National Academies Press (US); 2010.

Order | Check Discount

Tags: Homework help, I need help writing, Pathophysiology of Cardiac Remodeling in Heart Failure: Mechanisms and Therapeutic Targets, Write my assignment

Assignment Help For You!

Special Offer! Get 20-25% Off On your Order!

Why choose us

You Want Quality and That’s What We Deliver

Top Skilled Writers

To ensure professionalism, we carefully curate our team by handpicking highly skilled writers and editors, each possessing specialized knowledge in distinct subject areas and a strong background in academic writing. This selection process guarantees that our writers are well-equipped to write on a variety of topics with expertise. Whether it's help writing an essay in nursing, medical, healthcare, management, psychology, and other related subjects, we have the right expert for you. Our diverse team 24/7 ensures that we can meet the specific needs of students across the various learning instututions.

Affordable Prices

The Essay Bishops 'write my paper' online service strives to provide the best writers at the most competitive rates—student-friendly cost, ensuring affordability without compromising on quality. We understand the financial constraints students face and aim to offer exceptional value. Our pricing is both fair and reasonable to college/university students in comparison to other paper writing services in the academic market. This commitment to affordability sets us apart and makes our services accessible to a wider range of students.

100% Plagiarism-Free

Minimal Similarity Index Score on our content. Rest assured, you'll never receive a product with any traces of plagiarism, AI, GenAI, or ChatGPT, as our team is dedicated to ensuring the highest standards of originality. We rigorously scan each final draft before it's sent to you, guaranteeing originality and maintaining our commitment to delivering plagiarism-free content. Your satisfaction and trust are our top priorities.

How it works

When you decide to place an order with Nursing Essays, here is what happens:

Complete the Order Form

You will complete our order form, filling in all of the fields and giving us as much detail as possible.

Assignment of Writer

We analyze your order and match it with a writer who has the unique qualifications to complete it, and he begins from scratch.

Order in Production and Delivered

You and your writer communicate directly during the process, and, once you receive the final draft, you either approve it or ask for revisions.

Giving us Feedback (and other options)

We want to know how your experience went. You can read other clients’ testimonials too. And among many options, you can choose a favorite writer.