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Posted: July 4th, 2024

Gyromitra esculenta Toxicity Clinical Presentation

Gyromitra esculenta Toxicity: Clinical Presentation, Mortality, and Mechanisms
This paper examines the toxicity associated with Gyromitra esculenta mushroom ingestion, focusing on clinical manifestations, mortality rates, therapeutic approaches, and the underlying mechanisms of toxicity.
Signs and Symptoms of Gyromitra esculenta Toxicity
Gyromitra esculenta, commonly known as the false morel, contains the toxin gyromitrin, which is metabolized to monomethylhydrazine (MMH) in the body. The clinical presentation of Gyromitra esculenta poisoning typically develops within 6-12 hours after ingestion and may include a range of gastrointestinal, neurological, and hepatic symptoms (Berger and Guss, 2005).
Gastrointestinal symptoms often appear first and include nausea, vomiting, and abdominal pain. As the toxicity progresses, neurological manifestations may emerge, such as headache, dizziness, fatigue, and in severe cases, seizures or coma. Hepatotoxicity is another significant concern, potentially leading to elevated liver enzymes, jaundice, and in extreme cases, liver failure (Michelot and Melendez-Howell, 2003).
In some instances, patients may experience hemolysis, resulting in hemolytic anemia. Methemoglobinemia can also occur, leading to cyanosis and respiratory distress. Rhabdomyolysis has been reported in severe cases, which may contribute to acute kidney injury (Horowitz and Moss, 2020).
Mortality and Therapeutic Approaches
The mortality rate associated with Gyromitra esculenta poisoning varies depending on the amount ingested and the timeliness of medical intervention. Historically, mortality rates were reported to be as high as 20-30%. However, with improved recognition and management of the condition, current estimates suggest a mortality rate of less than 5% in developed countries with access to advanced medical care (Berger and Guss, 2005).
Treatment for Gyromitra esculenta poisoning primarily involves supportive care and symptomatic management. Gastric decontamination may be considered if presentation occurs shortly after ingestion, although its efficacy is limited due to the rapid absorption of the toxin. Intravenous fluid resuscitation is crucial to maintain hydration and support renal function (Horowitz and Moss, 2020).
A key therapeutic approach involves the administration of pyridoxine (vitamin B6). Pyridoxine serves as a cofactor for the enzyme glutamic acid decarboxylase, which is inhibited by gyromitrin metabolites. High-dose pyridoxine therapy (25 mg/kg IV) has shown efficacy in managing neurological symptoms and reducing the risk of seizures (Michelot and Melendez-Howell, 2003).
In cases of severe methemoglobinemia, methylene blue may be administered to restore oxygen-carrying capacity. Hepatoprotective agents and N-acetylcysteine have been used to mitigate liver damage, although their efficacy in this specific toxicity remains uncertain. In extreme cases of fulminant hepatic failure, liver transplantation may be considered (Berger and Guss, 2005).
Mechanisms of Toxicity
The primary toxin in Gyromitra esculenta, gyromitrin, is hydrolyzed in the gastrointestinal tract to form monomethylhydrazine (MMH). MMH exerts its toxic effects through multiple mechanisms, primarily affecting the central nervous system, liver, and red blood cells (Horowitz and Moss, 2020).
In the central nervous system, MMH interferes with gamma-aminobutyric acid (GABA) synthesis by inhibiting glutamate decarboxylase. This inhibition leads to a reduction in GABA levels, potentially resulting in seizures and other neurological symptoms. Additionally, MMH may interact with pyridoxal phosphate, a crucial cofactor for numerous enzymatic reactions, further disrupting neurotransmitter balance (Michelot and Melendez-Howell, 2003).
Hepatotoxicity induced by MMH is believed to result from the formation of free radicals and subsequent oxidative stress. These processes can lead to lipid peroxidation and cellular damage in hepatocytes. The toxin may also interfere with mitochondrial function, further compromising cellular energy production and viability (Berger and Guss, 2005).
MMH can oxidize hemoglobin to methemoglobin, reducing the oxygen-carrying capacity of red blood cells and potentially leading to tissue hypoxia. Furthermore, MMH may cause direct damage to red blood cell membranes, resulting in hemolysis (Horowitz and Moss, 2020).
In conclusion, Gyromitra esculenta toxicity presents a complex clinical picture with multi-organ involvement. While mortality rates have decreased with improved medical management, prompt recognition and appropriate supportive care remain crucial for optimal patient outcomes. Further research into the precise mechanisms of toxicity may lead to the development of more targeted therapeutic approaches in the future.
References
Berger, K.J. and Guss, D.A., 2005. Mycotoxins revisited: Part I. Journal of Emergency Medicine, 28(1), pp.53-62.
Horowitz, B.Z. and Moss, M.J., 2020. Amatoxin mushroom toxicity. In StatPearls [Internet]. StatPearls Publishing.
Michelot, D. and Melendez-Howell, L.M., 2003. Amanita muscaria: chemistry, biology, toxicology, and ethnomycology. Mycological Research, 107(2), pp.131-146.
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History: A 33-year-old chef presents to your emergency department with vomiting.
He prepared a meal using the mushroom Gyromitra esculenta, but later
learned that they are toxic. He ate only a small amount.
PMH: None.
Physical Examination:
T: 98.6°F HR: 80 bpm RR: 18 breaths per minute BP: 120/76 mm Hg
General: Awake and alert.
HEENT: Examination is normal.
Pulmonary: Clear to auscultation.
CV: Regular rate and rhythm without murmur.
Abdomen: Soft and nontender.
Neurologic: Cranial nerves II-XII intact. Muscle strength is normal.
QUESTIONS CASE STUDY #18
1. What are signs and symptoms of a Gyromitra esculenta overdose?
2. What is the mortality for this type of ingestion? Are there special therapies?
3. How does this toxin work?

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Tags: and Mechanisms, Gyromitra esculenta Toxicity, Mortality

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